2-Amino-1-(3-chlorophenyl)ethan-1-ol → HCID 19874536, compound

HRID 465465Notes

Reaction equation

HRID 465465 reaction equation
[CH3:1][C:2]1([C:19]([NH2:21])=[O:20])[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16]([CH3:18])=O)=[CH:11][CH:10]=2)[O:3]1.[OH:22][CH:23]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[CH:27]=1)[CH2:24][NH2:25]>>[CH3:1][C:2]1([C:19]([NH2:21])=[O:20])[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([NH:25][CH2:24][CH:23]([OH:22])[C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[CH:27]=3)[CH3:18])=[CH:11][CH:10]=2)[O:3]1

Participants

3

Reactant 2

HCID 37516012-Amino-1-(3-chlorophenyl)ethan-1-olHCID 19874553HCID 19874553, compound

Product 1

HCID 19874536HCID 19874536, compound

Procedure

Methyl 5-[4-[2-[(3-chloro-β-hydroxyphenethyl)amino] propyl]phenoxymethyl]tetrahydrofuran-2-carboxamide was prepared from methyl 5-[4-acetonylphenoxymethyl]tetrahydrofuran-2-carboxamide and 2-hydroxy-2-(3-chlorophenyl)ethanamine in an analogous manner to the compound described in Example 50.

Sources & evidence

ORD record
ord-3c99f7f1bb9241189858a3d0b4643140
Source dataset
uspto-grants-1992_10
Patent number
US05153210

Reaction notes

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