Hydrochloric Acid → HCID 10680224, compound

Participants

Reaction Steps

(4-Acetamidophenylsulphonyl)nitromethane (obtained as described in J Het. Chem., 1977, 14, 1415) (10.0 g, 38.8 mmol) was added in one portion to a boiling mixture of concentrated hydrochloric acid (20 ml), water (100 ml) and ethanol (40 ml). The mixture was stirred at reflux until a clear solution formed (about 20 minutes) and then for a further 5 mins. The hot reaction mixture was poured into an excess of ice-cold saturated sodium bicarbonate solution and then extracted with ethyl acetate. The combined extracts were washed with brine, dried (MgSO4) and the solvent was removed by evaporation. There was thus obtained (4 aminophenylsulphonyl)nitromethane as a pale yellow solid (5.2 g, 62% yield), m.p. 132°-133° C., microanalysis, found: C, 39.2; H, 3.8: N, 12.9%; C7H8N2O4S requires: C, 38.9; H, 3.7; N, 12.95%.

Provenance & Evidence