2-Amino-5-bromo-1,3,4-thiadiazole → N-[3-[3-[(2,6-Dimethyl-1-piperidinyl)methyl]phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

HRID 4655Notes

Reaction equation

HRID 4655 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH3:8])[N:3]1[CH2:9][C:10]1[CH:11]=[C:12]([CH:18]=[CH:19][CH:20]=1)[O:13][CH2:14][CH2:15][CH2:16][NH2:17].Br[C:22]1[S:26][C:25]([NH2:27])=[N:24][N:23]=1>>[CH3:8][CH:4]1[CH2:5][CH2:6][CH2:7][CH:2]([CH3:1])[N:3]1[CH2:9][C:10]1[CH:11]=[C:12]([CH:18]=[CH:19][CH:20]=1)[O:13][CH2:14][CH2:15][CH2:16][NH:17][C:22]1[S:26][C:25]([NH2:27])=[N:24][N:23]=1

Participants

3

Reactant 2

HCID 36508832-Amino-5-bromo-1,3,4-thiadiazoleHCID 542933513-[3-[(2,6-Dimethyl-1-piperidinyl) methyl]phenoxy]-1-propanamine

Product 1

HCID 20151490N-[3-[3-[(2,6-Dimethyl-1-piperidinyl)methyl]phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

Procedure

The compound is prepared by a method analogous to that of Example 51 from 3-[3-[(2,6-dimethyl-1-piperidinyl) methyl]phenoxy]-1-propanamine and 5-bromo-1,3,4-thiadiazole-2-amine.

Sources & evidence

ORD record
ord-292aa25057144f35afec883a6f5179f1
Source dataset
uspto-grants-1988_02
Patent number
US04727081

Reaction notes

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