HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → Diethyl [4-aminobutyl][3-(3-pyridyl)propyl]-malonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Propanedioic acid, (4-azidobutyl)[3-(3-pyridinyl)propyl]-, diethyl ester | HCID 10068124 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Diethyl [4-aminobutyl][3-(3-pyridyl)propyl]-malonate | HCID 10383244 | — |
Reaction Steps
To a solution of 42.59 g (0.11 mole) of diethyl [4-azidobutyl][3-(3-pyridyl)propyl]malonate in 270 ml THF and 3.1 ml water is added 29 g (0.11 mole) of triphenyl phosphine and the solution is stirred well for 48 h. Solvent is evaporated and the residue subjected to flash chromatography to give diethyl [4-aminobutyl][3-(3-pyridyl)propyl]-malonate as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05153214 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-a31aa1a200af4b83acd2591e41618fa4 |
| Source note | uspto-grants-1992_10 |