Ammonia → HCID 10107615, compound

Participants

Reaction Steps

To a solution of 0.1 g (0.37 mmol) of methyl 7-cyano-5-[2-(3-pyridyl)ethyl]-heptanoate in 20 ml of methanol saturated with ammonia is added 0.15 ml Raney Nickel and the mixture is hydrogenated at 3 atmospheres (=3.04 bar) pressure of hydrogen and room temperature for 4 h. The catalyst is filtered off and washed with methanol (4×20 ml). The filtrate is evaporated to give methyl 8-amino-5-[2-(3-pyridyl)ethyl]-octanoate.

Provenance & Evidence