Sodium Hydroxide → HCID 10410915, compound

Participants

Reaction Steps

A mixture of 0.083 g (0.18 mmol) of methyl 8-(p-chlorophenylsulfonamido)-5-[2-(3-pyridyl)ethyl]-octanoate (example 8), 2 ml dioxane and 0.4 ml (0.4 mmol) 1N aqueous sodium hydroxide is stirred for 16 h at room temperature. The solvent is evaporated and the residue taken up in water and the pH is adjusted to 5. The aqueous mixture is then extracted with methylene chloride (4×10 ml). Combined organic extract is dried (MgSO4), filtered and evaporated to give an oil which is crystallized from ether to give 8-(p-chlorophenylsulfonamido)-5-[2-(3-pyridyl)ethyl]-octanoic acid, m.p. 83°-85°.

Provenance & Evidence