4-Chlorobenzenesulfonyl chloride → HCID 14986640, compound

Participants

Reaction Steps

Methyl 8-amino-6-(3-pyridylmethyl)-octanoate (0.5 g) is dissolved in 50 ml of methylene chloride and 3 ml of triethylamine is added. To this solution is added dropwise a solution of 0.5 g of p-chlorophenylsulfonyl chloride in 10 ml of methylene chloride. The reaction mixture is stirred at room temperature for 1 h, the solvent is evaporated and the residue thus obtained purified by chromatography over silica gel, using methylene chloride as eluent to obtain methyl 8-(p-chlorophenylsulfonamido)-6-(3-pyridylmethyl)-octanoate as an oil.

Provenance & Evidence