Sodium Hydroxide → HCID 10478768, compound

Participants

Reaction Steps

Methyl 8-(p-chlorophenylsulfonamido)-6-(3-pyridylmethyl)-octanoate of example 11 (0.3 g) is dissolved in 10 ml of methanol, 20 ml of 1N aqueous NaOH added and the reaction is stirred at room temperature overnight. The methanol is evaporated off, water added and the mixture extracted with ethyl acetate. The aqueous layer is acidified to pH 6.1 and extracted with ethyl acetate. The ethyl acetate extract is dried over magnesium sulfate, filtered and concentrated to give 8-(p-chlorophenylsulfonamido)-6-(3-pyridylmethyl)-octanoic acid, NMR (CDCl3): delta 7.7 (d,2H), 7.4 (d,2H), 2.9 (m,2H).

Provenance & Evidence