HCID 11742328, compound → HCID 45262174, compound

Participants

Reaction Steps

A solution of 8 g of methyl 7-(p-chlorophenylsulfonamido)-6-(3-pyridyl)heptanoate in 100 ml of methanol and 100 ml of 1N aqueous sodium hydroxide is stirred at room temperature for 24 h, then evaporated to remove the methanol and acidified with 1N hydrochloric acid. The mixture is then extracted with ethyl acetate, the extract is dried over magnesium sulfate, filtered and evaporated, and the residue is treated with a saturated solution of HCl gas in ethyl acetate to yield 7-(p-chlorophenylsulfonamido)-6-(3-pyridyl)-heptanoic acid hydrochloride, m.p. 169°-172°.

Provenance & Evidence