Triethylamine → HCID 10250599, compound

Participants

Reaction Steps

A solution of 0.094 g (0.29 mmol) ethyl 8-hydroxy-4-[3-(3-pyridyl)propyl]-3-thiaoctanoate in 1.5 ml methylene chloride is cooled to 0° and then 0.1 ml of triethylamine is added followed by 0.027 ml methylsulfonyl chloride. The reaction mixture is stirred at 0° for 1 h and diluted with ether. The ether layer is washed with saturated sodium bicarbonate, water, brine, then dried, filtered and evaporated to yield ethyl 8-methylsulfonyloxy-4-[3-(3-pyridyl)propyl]-3-thia-octanoate; NMR (CDCl3): delta 3.2 (s,2H), 3.1 (s,3H).

Provenance & Evidence