Potassium Carbonate → HCID 19874793, compound

Participants

Reaction Steps

A mixture of 2.0 g (12.8 mmol) ethyl 2-oxocyclopentanecarboxylate, 5.71 g (25.6 mmol) 1-(tetrahydropyranyloxy)-3-bromopropane, 7.08 g (52.2 mmol) powdered potassium carbonate and 60 ml acetone is heated to 60° under nitrogen with stirring for 8 h. The reaction mixture is cooled to room temperature, filtered and evaporated to give a yellow orange liquid which is purified by flash chromatography using 1:9 ethyl acetate/hexane to yield 2-[3-(tetrahydropyranyloxy)propyl]-2-ethoxycarbonylcyclopentanone; IR (neat): 1750, 1724 cm-1.

Provenance & Evidence