Ammonia → HCID 14986682, compound

Participants

Reaction Steps

A mixture of 0.5 g (1.67 mmol) 2-[3-(tetrahydropyranyloxy)propyl]-2-ethoxycarbonylcyclopentanone and 5 ml ethanol is saturated with ammonia gas at 5° in a thick-wall tube. The tube is sealed and heated to 80° for 17 h. The reaction mixture is cooled and then subjected to evaporation. The resulting oil is chromatographed using 4:1 ethylacetate/hexane +1% aqueous ammonia to yield 5-ethoxycarbonyl-5-[3-(tetrahydropyranyloxy)propyl]-valeramide; IR (neat): 3413, 3349, 1727, 1668 cm-1.

Provenance & Evidence