Tetrahydrofuran → HCID 14986683, compound

Participants

Reaction Steps

A solution of 1.0 g (3.17 mmol) of 5-[3-(tetrahydropyranyloxy)propyl]valeramide in 5 ml tetrahydrofuran is added dropwise to a suspension of 0.481 g (12.68 mmol) lithium aluminium hydride in 20 ml dry tetrahydrofuran. The reaction mixture is refluxed for 2.5 h, cooled in an ice-bath and quenched by the addition of 0.5 ml water, 0.5 ml 15% aqueous sodium hydroxide followed by 1.5 ml water. The mixture is stirred for 15 min and filtered, washed and then subjected to evaporation to give 6-amino-2-[3-(tetrahydropyranyloxy)propyl]-hexan-1-ol.

Provenance & Evidence