Tributyltin azide → HCID 178526988, compound

Participants

Reaction Steps

A mixture of 0.528 g 8-(p-chlorophenylsulfonamido)-4-[3-(3-pyridyl)propyl]-octanenitrile and 1.04 ml tributyltin azide in 5 ml tetrahydrofuran is heated at 120° for 64 h. The solvent is evaporated and subjected to flash chromatography over silica gel using methylene chloride/hexane/methanol/acetic acid (45:25:5:0.8) as eluent to give an oil which is purified again by preparative thin layer chromatography using methylene chloride/hexane/methanol/acetic acid (45:25:5:0.8) as eluent to yield an oil which is triturated with ether and hexane to give 5-{7-(p-chlorophenylsulfonamido)-3-[3-(3-pyridyl)propyl]-heptyl}-1H-tetrazole hemihydrate, m.p. 56°-81°.

Provenance & Evidence