2-Amino-5-bromo-1,3,4-thiadiazole → N-[3-[3-[(3,5-Dimethyl-1-piperidinyl)methyl]phenoxy]propyl]-1,3,4-thiadiazole-2,5-diamine

HRID 4656Notes

Reaction equation

HRID 4656 reaction equation
[CH3:1][CH:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]2[CH:11]=[C:12]([CH:18]=[CH:19][CH:20]=2)[O:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH2:3]1.Br[C:22]1[S:26][C:25]([NH2:27])=[N:24][N:23]=1>>[CH3:8][CH:6]1[CH2:7][CH:2]([CH3:1])[CH2:3][N:4]([CH2:9][C:10]2[CH:11]=[C:12]([CH:18]=[CH:19][CH:20]=2)[O:13][CH2:14][CH2:15][CH2:16][NH:17][C:22]2[S:26][C:25]([NH2:27])=[N:24][N:23]=2)[CH2:5]1

Participants

3

Reactant 2

HCID 36508832-Amino-5-bromo-1,3,4-thiadiazoleHCID 540403033-[3-[(3,5-Dimethyl-1-piperidinyl) methyl]phenoxy]-1-propanamine

Product 1

HCID 20151498N-[3-[3-[(3,5-Dimethyl-1-piperidinyl)methyl]phenoxy]propyl]-1,3,4-thiadiazole-2,5-diamine

Procedure

The compound is prepared by a method analogous to that of Example 51 from 3-[3-[(3,5-dimethyl-1-piperidinyl) methyl]phenoxy]-1-propanamine and 5-bromo-1,3,4-thiadiazole-2-amine.

Sources & evidence

ORD record
ord-aaf7956a33af4e4cbdda27dc4ddd228e
Source dataset
uspto-grants-1988_02
Patent number
US04727081

Reaction notes

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