反应详情

Thionyl chloride (1.125 l, 1.835 kg, 15.42 mol) is cooled to 0°, and dimethylformamide (1.199 l, 1.132 kg, 15.50 mol) is added dropwise over a period of 2 h keeping the temperature below 10°. After the addition is complete the reaction is allowed to come to room temperature over 2 h. To this is then added 5-methoxycarbonyl-oct-7-enoic acid amide (see example 22c), 2.671 kg, 13.42 mol) neat over a period of 3 h. The reaction is allowed to stir at room temperature for 18 h and is combined with material from a similar run and then diluted with diethyl ether (35 l). The solution is cooled to 0° and is admixed with 8 kg of ice and 12 l of water. The mixture is stirred for 30 min and is then basified with aqueous ammonia (12 l, 2.5M). The layers are separated and the organic phase is washed with water (12 l) and brine (12 l) and dried over anhydrous sodium sulfate (7.5 kg). This is then filtered and evaporated to yield a crude oil which is redissolved in diethyl ether (24 l) and this solution is stirred over 7 kg of silica gel for several h. After filtration and evaporation there is obtained partially purified material which is then distilled to obtain 5-methoxycarbonyl-oct-7-enenitrile, b.p. 118°-120°/0.15 mm Hg (=0.20 mbar).

1. customthe temperature below 10°
2. additionAfter the addition
3. temperatureThe solution is cooled to 0°
4. stirringThe mixture is stirred for 30 min
5. customThe layers are separated
6. washthe organic phase is washed with water (12 l) and brine (12 l)
7. dry with materialdried over anhydrous sodium sulfate (7.5 kg)
8. filtrationThis is then filtered
9. customevaporated
10. customto yield a crude oil which
11. stirringthis solution is stirred over 7 kg of silica gel for several h
12. filtrationAfter filtration
13. customevaporation there
14. customis obtained partially purified material which
15. distillationis then distilled