Sodium Hydroxide → HCID 19874746, compound

Participants

Reaction Steps

Ethyl 8-(p-chlorophenylsulfonamido)-5-(3-pyridyloxy)-octanoate is hydrolyzed with 1N aqueous sodium hydroxide and dioxane and the product is purified using preparative thin layer chromatography on silica gel using 4:1 ethyl acetate/hexane with 1% acetic acid as eluent to give 8-(p-chlorophenylsulfonamido)-5-(3-pyridyloxy)-octanoic acid; 1H-NMR (CDCl3): delta 8.16 (brs,1H), 8.08 (d,1H), 4.39 (m,1H), 2.86 (t,2H).

Provenance & Evidence