Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 10243752 | HCID 10243752 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10381747 | HCID 10381747 | — |
Reaction Steps
To a solution of (-)-2(R)-allyl-6-(benzyloxy)-hexan-1-ol (5.0 g, 20 mmol) in methylene chloride (85 ml) at 0° C. is added triethylamine (4.6 ml, 33 mmol) followed by methanesulfonyl chloride. The mixture is allowed to stir at 0° C. for 2 hours and then quenched using saturated sodium bicarbonate solution. The organic layer is separated, dried, filtered and evaporated to give (-)-2(R)-allyl-6-(benzyloxy)hexan-1-yl methanesulfonate (mesylate ester) which is used as is.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05153214 |
|---|
| Source dataset | uspto-grants-1992_10 |
|---|
| ORD ID | ord-8632f73dad394befabc52ae4b6d9483d |
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| Source note | uspto-grants-1992_10 |
|---|
