反应详情

To a mixture of the product of Example 6 (0.45 g) and excess triethylamine at room temperature was added 0.22 g p-toluene sulfonyl chloride. This mixture was diluted with ethyl acetate, concentrated, and triethylamine and ethyl acetate added a second time. The reaction mixture was then concentrated to a brown oil. After sitting 5 days at room temperature, the oil was taken up in ethyl acetate, washed with NaHCO3 and NaCl solutions, dried over MgSO4, filtered, and concentrated to an oil. The oil was purified by chromatography on silica gel using hexane/EtoAc, 8/21 as eluant. The appropriate fractions were concentrated to an oil which crystallized upon trituration with hexane. 0.44 g (69%). NMR (CDCl3) δ 1.17 (6H, d), δ 1.64-1.82 (4H, m), δ 2.03 (4H, m), δ 2.42 (3H, s), δ 2.97 (2H, m), δ 3.42 (2H, s), δ 3.55 (2H, s), δ 7.13-7.65 (12H, m). IR (KBr) 3370, 2965, 2870, 1673, 1497, 1328, 1158, 1092, 755, 550 cm-1.

1. concentrationconcentrated
2. additiontriethylamine and ethyl acetate added a second time
3. concentrationThe reaction mixture was then concentrated to a brown oil
4. washwashed with NaHCO3 and NaCl solutions
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated to an oil
8. customThe oil was purified by chromatography on silica gel
9. concentrationThe appropriate fractions were concentrated to an oil which
10. customcrystallized upon trituration with hexane