Carbamate → HCID 54132018, compound

HRID 465642Notes

Reaction equation

CC([N:5]([C@@H:9]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:25][CH:24]=1)[C:10](=[O:21])[NH:11][C:12]1[C:17]([F:18])=[CH:16][C:15]([F:19])=[CH:14][C:13]=1[F:20])C(=O)[O-])(C)C.C(=O)([O-])N>>[NH2:5][C@@H:9]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:25][CH:24]=1)[C:10]([NH:11][C:12]1[C:17]([F:18])=[CH:16][C:15]([F:19])=[CH:14][C:13]=1[F:20])=[O:21]

Participants

Reactant 2

HCID 276Carbamate

HCID 86746181HCID 86746181, compound

Product 1

HCID 54132018HCID 54132018, compound

Procedure

Employing the method of Example 22, but using (S)-1,1-dimethylethyl[2-oxo-1-[[4-(phenylmethoxy)phenyl]methyl]-2-[(2,4,6-trifluorophenyl)amino]ethyl]carbamate instead of (S)-1,1-dimethylethyl[[2,6-bis(1-Methylethyl)phenyl]amino]-2-oxo-1-[[4-(phenylmethoxy)phenyl]methyl]ethyl]carbamate, the title compound was prepared, mp 80.5°-86.5° C.

Sources & evidence

ORD record: ord-4bbf710101af4fa3baa12457a1107d88
Source dataset: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05153226

Reaction notes

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