Methyl 2-chloroacrylate → 5-Chloro-5-methoxycarbonyl-3-thiapentanamide

Participants

Reaction Steps

2-Mercaptoacetamide (18.79 g) was stirred in a mixture of dry 1,4-dioxan (200 ml) and dry pyridine (33.5 ml)) whilst methyl 2-chloroacrylate (24.88 g) was added dropwise over 15 minutes. The mixture was stirred for 1 hour then stood overnight. The resultant mixture contained the title compound.

Provenance & Evidence