2-Amino-5-bromo-1,3,4-thiadiazole → N-[3-[3-[(4-Methyl-1-piperidinyl)methyl]phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

HRID 4657Notes

Reaction equation

HRID 4657 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:17]=[CH:18][CH:19]=2)[O:12][CH2:13][CH2:14][CH2:15][NH2:16])[CH2:4][CH2:3]1.Br[C:21]1[S:25][C:24]([NH2:26])=[N:23][N:22]=1>>[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:17]=[CH:18][CH:19]=2)[O:12][CH2:13][CH2:14][CH2:15][NH:16][C:21]2[S:25][C:24]([NH2:26])=[N:23][N:22]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 36508832-Amino-5-bromo-1,3,4-thiadiazoleHCID 133646653-{3-[(4-Methylpiperidin-1-yl)methyl]phenoxy}propan-1-amine

Product 1

HCID 20151508N-[3-[3-[(4-Methyl-1-piperidinyl)methyl]phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

Procedure

The compound is prepared by a method analogous to that of Example 51 from 3-[3-[(4-methyl-1-piperidinyl)methyl]phenoxy]-1-propanamine and 5-bromo-1,3,4-thiadiazole-2-amine.

Sources & evidence

ORD record
ord-240cfb306ec74f67bf05dd8b84d5b09c
Source dataset
uspto-grants-1988_02
Patent number
US04727081

Reaction notes

Loading…