1,3-Isobenzofurandione, 5-fluoro- → HCID 57283400, compound

Participants

Reaction Steps

4-Fluorophthalic anhydride (16.7 g, 100 mmol) and sodium benzoate (14.5 g, 101 mmol) were heated to about 145° C. in DMF (70 ml). After heating for 5 hours, the solvent was distilled off under reduced pressure (the temperature was kept at less than 100° C.). Ethyl acetate (50 ml) was added and the suspension refluxed for 30 minutes. The suspension was filtered and the ethyl acetate allowed to cool to give 4-benzoyloxyphthalic anhydride (13.6 g, 86% pure) as a whitish solid. Ethyl acetate (8 mls) was distilled from the mother liquor and hexane added to the hot solution. The solution was allowed to cool and stand for several days upon which a solid benzoyloxyphthalic anhydride precipitated (4.7 g, 79% pure).

Provenance & Evidence