反应详情

A mixture of 2.0 g. of 1-methyl-3-phenyl-5-(3-trifluoromethylphenyl)-4(1H)-pyridinethione and 10 ml. of benzyl chloride in benzene was heated under reflux for 6 hours. The mixture was cooled and the benzene was removed in vacuo. The residue was put on a silica gel column in benzene and the column was flushed with benzene. The product was then removed from the column with denatured ethanol. The ethanol was removed and the residue was crystallized from ether yielding 0.7 g. of 4-benzylthio-1-methyl-3-phenyl-5-(3-trifluoromethylphenyl)pyridinium chloride, m.p. 70°-73°.

1. additionA mixture of 2.0 g
2. temperatureunder reflux for 6 hours
3. temperatureThe mixture was cooled
4. customthe benzene was removed in vacuo
5. customthe column was flushed with benzene
6. customThe product was then removed from the column with denatured ethanol
7. customThe ethanol was removed
8. customthe residue was crystallized from ether yielding 0.7 g