Water → Aspirin

HRID 465901Notes

Reaction equation

HRID 465901 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].[C:5]([OH:14])(=[O:13])[C:6]1[C:7](=[CH:9][CH:10]=[CH:11][CH:12]=1)O.O>C(O)C>[CH3:2][C:1]([O:4][C:12]1[CH:11]=[CH:10][CH:9]=[CH:7][C:6]=1[C:5]([OH:14])=[O:13])=[O:3]

Participants

4

Reactant 2

HCID 962WaterHCID 17872858HCID 17872858, compound3×

Product 1

HCID 2244Aspirin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
22.5 °C

Procedure

To prepare a suspension, desalted egg phosphatides (Hepar) were dissolved in ethanol at a concentration of 250 mg/ml in a 1000 ml flask. To 400 mg of salicylic acid acetate, 1.6 ml of the above solution containing 400 mg of phosphatides was added and the solution adjusted with absolute ethanol to 4 ml. The final concentration of both ingredients in this pharmacological agent-lipid solution was 100 mg/ml. This procedure was performed at about 22.5° C.+/- about 2.5° C. and atmospheric pressure. Then 0.5 ml of the salicylic acid acetate-lipid solution was added to 9.5 ml of distilled water and briefly shaken by hand, at about 22.5° C.+/- about 2.5° C. and atmospheric pressure forming a suspension. The resulting suspension was milky in appearance and did not contain visable crystals or aggregates after a 30 minute period. Light microscopy of the suspension revealed aggregates, primarily with a diameter below 5 microns and no crystal characteristic for salicylic acid acetate. This suspension contained 0.5 mg salicylic acid acetate/ml.

Workup

  1. customTo prepare a suspension
  2. additionwas added
  3. customwas performed at about 22.5° C.
  4. customforming a suspension
  5. customafter a 30 minute

Sources & evidence

ORD record
ord-3667077a976e473cb254ecd697b271db
Source dataset
uspto-grants-1992_10
Patent number
US05154930

Reaction notes

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