Triethylamine → HCID 14719516, compound

Participants

Reaction Conditions

Reaction Steps

In the meantime, 6.00 g of 2-hydroxy-3-n-propyl-4-methoxy-benzoic acid was dispersed in 120 ml of methylene chloride, and the dispersion was cooled to -10° C. To the dispersion were added 9.93 ml of triethylamine and 5.45 ml of ethyl chlorocarbonate, and the mixture was agitated for 30 minutes. To the mixture was added the mixture of 2-aminoethyl-n-octylsulfide and hydrazide which had been dispersed in methylene chloride. The mixture was agitated at -10° C. to 0° C. for 3 hours. The reaction mixture was filtered, and the precipitate was washed with methylene chloride. The filtrate and the wash solution was combined, washed with water and then with saturated aqueous solution of sodium chloride, and dried over anhydrous sodium sulfate. The solvent was distilled off in evacuated atomosphere, and the residue was subjected to column chromatography using silica gel. There was obtained 6.28 g of 2-(2'-ethoxycarbonyloxy-3'-n-propyl-4'-methoxybenzoylamino)ethyl-n-octylsulfide.

Provenance & Evidence