反应详情

To a solution of 10.0 g of 3-acetoxy-2,2-dimethyl-1-propanesulfonamide in 80 ml of methanol was added 9.2 g of 28 W/W % sodium methoxide methanol solution at room temperature with stirring. After stirring for 30 minutes, the reaction mixture was concentrated to dryness, and the residue was subjected to a silica gel column chromatography, eluting with chloroform-methanol (9:1). The corresponding fractions were concentrated to obtain 6.2 g of 3-hydroxy-2,2,-dimethyl-1-propanesulfonamide.

1. stirringAfter stirring for 30 minutes
2. concentrationthe reaction mixture was concentrated to dryness
3. washeluting with chloroform-methanol (9:1)
4. concentrationThe corresponding fractions were concentrated