6-[(2,2-Dimethyl-3-sulfamoylpropyl)oxy]imidazo[1,2-b]pyridazine → 6-[(2,2-Dimethyl-3-sulfamoylpropyl)oxy]imidazo[1,2-b]pyridazine hydrochloride

HRID 465947Notes

Reaction equation

HRID 465947 reaction equation
[ClH:1].CO.[CH3:4][C:5]([CH3:22])([CH2:17][S:18](=[O:21])(=[O:20])[NH2:19])[CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]2[N:12]([CH:14]=[CH:15][N:16]=2)[N:13]=1>CO>[ClH:1].[CH3:4][C:5]([CH3:22])([CH2:17][S:18](=[O:21])(=[O:20])[NH2:19])[CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]2[N:12]([CH:14]=[CH:15][N:16]=2)[N:13]=1

Participants

4

Reactant 2

HCID 100852846-[(2,2-Dimethyl-3-sulfamoylpropyl)oxy]imidazo[1,2-b]pyridazineHCID 21893726Hydrochloride methanol

Product 1

HCID 198151376-[(2,2-Dimethyl-3-sulfamoylpropyl)oxy]imidazo[1,2-b]pyridazine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

30% Hydrochloric acid-methanol solution (5 ml) was added to a solution of 1.71 g of 6-[(2,2-dimethyl-3-sulfamoylpropyl)oxy]imidazo[1,2-b]pyridazine in 100 ml of methanol. The mixture was concentrated under reduced pressure to dryness. The residue was recrystallized from ethanol to obtain 1.7 g of the title compound.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure to dryness
  2. customThe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-368af718e3374578ba517f61047b77d6
Source dataset
uspto-grants-1992_10
Patent number
US05155108

Reaction notes

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