6-[(2,2-Diethyl-3-sulfamoylpropyl)oxy]imidazo[1,2-b]pyridazine → 6-[(2,2-Diethyl-3-sulfamoylpropyl)oxy]imidazo[1,2-b]pyridazine hydrochloride

HRID 465949Notes

Reaction equation

HRID 465949 reaction equation
[ClH:1].CO.[CH2:4]([C:6]([CH2:23][CH3:24])([CH2:18][S:19](=[O:22])(=[O:21])[NH2:20])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]2[N:13]([CH:15]=[CH:16][N:17]=2)[N:14]=1)[CH3:5]>CO>[ClH:1].[CH2:23]([C:6]([CH2:4][CH3:5])([CH2:18][S:19](=[O:22])(=[O:21])[NH2:20])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]2[N:13]([CH:15]=[CH:16][N:17]=2)[N:14]=1)[CH3:24]

Participants

4

Reactant 2

HCID 98615706-[(2,2-Diethyl-3-sulfamoylpropyl)oxy]imidazo[1,2-b]pyridazineHCID 21893726Hydrochloride methanol

Product 1

HCID 198151396-[(2,2-Diethyl-3-sulfamoylpropyl)oxy]imidazo[1,2-b]pyridazine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

30% Hydrochloric acid-methanol solution (10 ml) was added to a solution of 6-[(2,2-diethyl-3-sulfamoyl-propyl) oxy]imidazo[1,2-b]pyridazine (3.0 g) in methanol (70 ml). The mixture was concentrated under reduced pressure to dryness. The residue was recrystallized from ethanol to obtain the above-identified compound (3.1 g).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure to dryness
  2. customThe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-f9caeb1d83ce4ba197cf47d94ab04339
Source dataset
uspto-grants-1992_10
Patent number
US05155108

Reaction notes

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