HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 6-Methyl-2-nitropyridin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 2-Methyl-5-hydroxypyridine | HCID 14275 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 6-Methyl-2-nitropyridin-3-ol | HCID 84801 | — |
Reaction Steps
5.45 g (50 mmol) of 5-hydroxy-2-methylpyridine are added to 20 ml of concentrated sulfuric acid while cooling in an ice bath. The temperature is maintained at +6° C. and 2.35 ml of fuming nitric acid are added with stirring. The mixture is left overnight at room temperature. 100 g of ice are added with stirring. The product is filtered off, rinsed with water and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05155116 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-c7dc370819044117b47a29b2dbd62110 |
| Source note | uspto-grants-1992_10 |