HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2-thioxopropionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-(2-Phenylpyrazolo[1,5-a]pyridine-3-yl)methylenerhodanine | HCID 54451617 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2-thioxopropionic acid | HCID 15158173 | — |
Reaction Steps
A mixture of 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)methylenerhodanine (13.0 g) and 15% aqueous solution of sodium hydroxide (50 ml) was refluxed for 3 hours. To the reaction mixture was added 10% hydrochloric acid (50 ml) and water (50 ml) and was stirred for an hour under ice-cooling. The precipitates were collected by filtration to give 3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2-thioxopropionic acid (7.85 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05155114 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-c59cf6cbda29462cabb9c0e49eb92aaa |
| Source note | uspto-grants-1992_10 |