Ethanol → 3-[3-{(E)-2-carboxyvinyl}pyridazin-4-yl]-2-phenylpyrazolo[1,5-a]pyridine

Participants

Reaction Steps

To an ethanol (12 ml) solution of 3-[3-(2-hydroxy-3,3,3-trichloropropyl)pyridazin-4-yl]-2-phenylpyrazolo[1,5-a]pyridine (1.20 g) was added 24% aqueous sodium hydroxide solution (4.8 ml), and refluxed for 5 hours. The reaction mixture was evaporated in vacuo and added 10% hydrochloric acid (12 ml). The precipitates were collected by filtration to give 3-[3-{(E)-2-carboxyvinyl}pyridazin-4-yl]-2-phenylpyrazolo[1,5-a]pyridine (0.64 g).

Provenance & Evidence