Hexanoyl chloride → 5-Chloro-2,4-dihexanoyloxypyridine

HRID 466111Notes

Reaction equation

[Cl:1][C:2]1[C:3]([OH:9])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[C:10](Cl)(=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>>[Cl:1][C:2]1[C:3]([O:9][C:10](=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:4][C:5]([O:8][C:10](=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[N:6][CH:7]=1

Participants

Reactant 2

HCID 67340Hexanoyl chloride

HCID 54679224Gimeracil

Product 1

HCID 140495975-Chloro-2,4-dihexanoyloxypyridineYield 34.9%

Procedure

The general procedure of Example 5 was followed using 2.00 g of 5-chloro-4-hydroxy-2-pyridone and 2.75 g of hexanoyl chloride to produce 1.22 g of the title compound in a yield of 26%.

Sources & evidence

ORD record: ord-4c74cb742da34a0faabf6139ba45cdb9
Source dataset: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05155113

Reaction notes

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