Water → HCID 14049670, compound

Participants

Reaction Steps

1.00 g of 4-hydroxy-2-pyridone was suspended in 50 ml of pyridine. After the addition of 3.65 g of isophthaloyl chloride, the suspension was refluxed with heating for 1.5 hours. The reaction mixture was left to stand for cooling, to which water was added and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over magnesium sulfate and concentrated under reduced pressure. The concentrate was washed with ether to give 1.00 g of the title compound in a yield of 43%.

Provenance & Evidence