Benzoyl chloride → HCID 14049676, compound

HRID 466128Notes

Reaction equation

HRID 466128 reaction equation
C[Si](C)(C)[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][Si](C)(C)C)[N:5]=1.[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(#N)C>[C:17]([O:3][C:4]1[NH:5][C:6](=[O:10])[CH:7]=[CH:8][CH:9]=1)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 14049642HCID 14049642, compound

Product 1

HCID 14049676HCID 14049676, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A 1.60 g quantity of 2,6-bis(trimethylsilyloxy)pyridine was dissolved in 10 ml of acetonitrile and 5 ml of acetonitrile solution containing 1.30 g of benzoyl chloride was added dropwise to the solution. After the mixture was reacted at room temperature for one day, the reaction mixture was concentrated and subjected to silica gel chromatography using chloroform as an eluent to produce 0.50 g of the title compound in a yield of 33%.

Workup

  1. additionwas added dropwise to the solution
  2. customAfter the mixture was reacted at room temperature for one day
  3. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-e8077f89036e4dabb79fa677cde296b3
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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