2-Thiophenecarbonyl chloride → HCID 14049648, compound

HRID 466135Notes

Reaction equation

HRID 466135 reaction equation
[C:1]1([C:6](Cl)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.[Cl:9][C:10]1[C:11]([OH:17])=[CH:12][C:13](=[O:16])[NH:14][CH:15]=1>N1C=CC=CC=1>[Cl:9][C:10]1[C:11]([O:17][C:6](=[O:7])[C:1]2[S:5][CH:4]=[CH:3][CH:2]=2)=[CH:12][C:13](=[O:16])[NH:14][CH:15]=1

Participants

4

Reactant 2

HCID 789282-Thiophenecarbonyl chlorideHCID 54679224Gimeracil

Product 1

HCID 14049648HCID 14049648, compoundYield 23%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 2.42 g quantity of 2-thenoyl chloride was added to a suspension of 2.00 g of 5-chloro-4-hydroxy-2-pyridone in 100 ml of pyridine, and the mixture was stirred at room temperature for 4.5 hours. The reaction mixture was concentrated and the concentrate was washed with ethyl acetate and water, thereby producing 0.82 g of the title compound in a yield of 23%.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe concentrate was washed with ethyl acetate and water

Sources & evidence

ORD record
ord-0202912b557748fdaa44bfbdd4dce013
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

Loading…