Phenoxyacetyl chloride → HCID 14049671, compound

HRID 466136Notes

Reaction equation

HRID 466136 reaction equation
[O:1]([CH2:8][C:9](Cl)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:12][C:13]1[CH:18]=[CH:17][NH:16][C:15](=[O:19])[CH:14]=1>N1C=CC=CC=1>[O:1]([CH2:8][C:9]([O:12][C:13]1[CH:18]=[CH:17][NH:16][C:15](=[O:19])[CH:14]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 69703Phenoxyacetyl chlorideHCID 546960044-Hydroxy-2(1H)-pyridinone

Product 1

HCID 14049671HCID 14049671, compoundYield 23%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 1.86 ml quantity of phenoxyacetyl chloride was added to a suspension of 1.00 g of 4-hydroxy-2-pyridone in 30 ml of pyridine, and the mixture was stirred at room temperature for four hours. The reaction mixture was concentrated and the concentrate was washed with ethyl acetate, water and chloroform in this order, thereby producing 500 mg of the title compound in a yield of 23%.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe concentrate was washed with ethyl acetate, water and chloroform in this order

Sources & evidence

ORD record
ord-5701a4b7f08f4d0f9b838040938e05f6
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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