Phenylacetyl chloride → HCID 14049650, compound

HRID 466141Notes

Reaction equation

HRID 466141 reaction equation
[C:1]1([CH2:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:11][C:12]1[C:13]([OH:19])=[CH:14][C:15](=[O:18])[NH:16][CH:17]=1>N1C=CC=CC=1>[Cl:11][C:12]1[C:13]([O:19][C:8](=[O:9])[CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:14][C:15](=[O:18])[NH:16][CH:17]=1

Participants

4

Reactant 2

HCID 7679Phenylacetyl chlorideHCID 54679224Gimeracil

Product 1

HCID 14049650HCID 14049650, compoundYield 14%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 3.63 ml quantity of phenylacetyl chloride was added to a suspension of 2.00 g of 5-chloro-4-hydroxy-2-pyridone in 60 ml of pyridine. The same subsequent procedure as in Example 39 was conducted, thereby producing 500 mg of the title compound in a yield of 14%.

Sources & evidence

ORD record
ord-935921bd86e84021baac847a667c3092
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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