Benzoyl chloride, 3,4,5-trimethoxy- → HCID 14049652, compound

HRID 466143Notes

Reaction equation

HRID 466143 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[C:6](Cl)=[O:7].[Cl:16][C:17]1[C:18]([OH:24])=[CH:19][C:20](=[O:23])[NH:21][CH:22]=1>N1C=CC=CC=1>[Cl:16][C:17]1[C:18]([O:24][C:6](=[O:7])[C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=2)=[CH:19][C:20](=[O:23])[NH:21][CH:22]=1

Participants

4

Reactant 2

HCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 54679224Gimeracil

Product 1

HCID 14049652HCID 14049652, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 3.80 g quantity of 3,4,5-trimethoxybenzoyl chloride was added to a suspension of 2.00 g of 5-chloro-4-hydroxy-2-pyridone in 100 ml of pyridine, and the mixture was stirred at room temperature for 2.5 hours. The reaction mixture was concentrated and the concentrate was washed with ethyl acetate and water, thereby producing 1.60 g of the title compound in a yield of 34%.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe concentrate was washed with ethyl acetate and water

Sources & evidence

ORD record
ord-31dcacebc8e444af852f09ddae88c45e
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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