1,3-Benzodioxole-5-carbonyl chloride → HCID 14049653, compound

Participants

Reaction Steps

A 3.80 g quantity of piperonyloyl chloride was added to a suspension of 2.00 g of 5-chloro-4-hydroxy-2-pyridone in 60 ml of pyridine, and the mixture was stirred at room temperature for 2.5 hours. The reaction mixture was filtered and the filtrate was concentrated. The concentrate was washed successively with ethyl acetate, water and chloroform and then purified by silica gel column chromatography using as an eluent 2% methanol-chloroform, thereby producing 200 mg of the title compound in a yield of 5%.

Provenance & Evidence