Benzyl 3-chlorocarbonylbenzoate → HCID 19815237, compound

HRID 466147Notes

Reaction equation

[Cl:1][C:2]1[C:3]([OH:9])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH2:10]([O:17][C:18]([C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23](Cl)=[O:24])=[O:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([O:17][C:18]([C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23]([O:9][C:3]1[C:2]([Cl:1])=[CH:7][NH:6][C:5](=[O:8])[CH:4]=1)=[O:24])=[O:19])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

Reactant 2

HCID 19815207Benzyl 3-chlorocarbonylbenzoate

HCID 54679224Gimeracil

Product 1

HCID 19815237HCID 19815237, compoundYield 29.8%

Procedure

The general procedure of Example 1 was followed using 2.20 g of 5-chloro-4-hydroxy-2-pyridone and 5.31 g of 3-benzyloxycarbonylbenzoyl chloride, thereby giving 1.73 g of the title compound in a yield of 29%.

Sources & evidence

ORD record: ord-dde0f6417796478aa57a062f9b0a3545
Source dataset: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05155113

Reaction notes

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