Valeryl chloride → 2-Oxo-1,2-dihydropyridin-4-yl pentanoate

HRID 466148Notes

Reaction equation

C[Si](C)(C)[O:3][C:4]1[CH:9]=[C:8]([O:10][Si](C)(C)C)[CH:7]=[CH:6][N:5]=1.[C:17](Cl)(=[O:22])[CH2:18][CH2:19][CH2:20][CH3:21]>>[C:17]([O:10][C:8]1[CH:7]=[CH:6][NH:5][C:4](=[O:3])[CH:9]=1)(=[O:22])[CH2:18][CH2:19][CH2:20][CH3:21]

Participants

Reactant 2

HCID 61186Valeryl chloride

HCID 21819823HCID 21819823, compound

Product 1

HCID 140496732-Oxo-1,2-dihydropyridin-4-yl pentanoateYield 41%

Procedure

The general procedure of Example 31 was followed using 1.00 g of 2,4-bis(trimethylsilyloxy)-pyridine and 1.02 ml of n-pentanoyl chloride, thereby giving 310 mg of the title compound in a yield of 41%.

Sources & evidence

ORD record: ord-282cad0db983439c9fb5d99ce8a06871
Source dataset: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05155113

Reaction notes

Loading…