4-Chlorobenzoyl chloride → 6-Benzoyloxy-2-(4-chlorobenzoyloxy)-3-cyanopyridine

HRID 466164Notes

Reaction equation

HRID 466164 reaction equation
[C:1]([O:9][C:10]1[N:15]=[C:14]([OH:16])[C:13]([C:17]#[N:18])=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>>[C:1]([O:9][C:10]1[N:15]=[C:14]([O:16][C:24](=[O:25])[C:23]2[CH:27]=[CH:28][C:20]([Cl:19])=[CH:21][CH:22]=2)[C:13]([C:17]#[N:18])=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 178510098HCID 178510098, compound

Product 1

HCID 140496406-Benzoyloxy-2-(4-chlorobenzoyloxy)-3-cyanopyridineYield 82.8%

Procedure

The general procedure of Example 90 was followed using 1.00 g of 6-benzoyloxy-3-cyano-2-hydroxypyridine and 0.72 g of 4-chlorobenzoyl chloride, thereby producing 1.29 g of the title compound in a yield of 82%.

Sources & evidence

ORD record
ord-7b2285d5154e4db49587bf58fb462ac1
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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