HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-benzyloxy-2H-1-benzopyran-3-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Hydroxychromene-3-carboxaldehyde | HCID 4770815 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-benzyloxy-2H-1-benzopyran-3-carboxaldehyde | HCID 14971260 | — |
Reaction Steps
A mixture of 6-hydroxy-2H-1-benzopyran-3-carboxaldehyde (25.0 g, 0.14 mol) and potassium carbonate (39.2 g, 0.28 mol) in 500 ml of DMF is treated with benzyl bromide (26.7 g, 0.16 mol). The mixture is stirred overnight at room temperature. Water is added and three extractions with dichloromethane are carried out. The extract is dried (MgSO4) and evaporated to dryness. The residue is crystallized from hot ethyl acetate to give 6-benzyloxy-2H-1-benzopyran-3-carboxaldehyde, m.p. 112°-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05155130 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-12f6cde40e39456691a1140d3910462e |
| Source note | uspto-grants-1992_10 |