2,6-Difluorobenzoyl isocyanate → HCID 19873185, compound

Participants

Reaction Conditions

Reaction Steps

2,6-Difluorobenzoyl isocyanate (1.8 g) was added to a solution of N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)-2-fluorophenyl)urea (3.2 g) in dry toluene (50 ml), and the resulting solution was stirred at ambient temperature (20° C.) for 48 hours. The product was then filtered from the reaction mixture, washed with a small amount of 1:2 v/v diethyl ether/light petroleum ether, and dried to yield N-(((((4-(2-chloro-4-(trifluoromethyl)phenoxy)-2-fluorophenyl)-amino)carbonyl)amino)carbonyl)-2,6-difluorobenzamide as a colourless crystalline solid (4.3 g, 90%), mp 190-192° C.

Provenance & Evidence