Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Actinomycin D | HCID 457193 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 6-Aminohexanoic Acid | HCID 564 | — |
Reaction Steps
Bromination with N-bromosuccinimide (NBS) is accomplished by adding 2.24 mmoles of actinomycin D in chlorobenzene to 2 mmoles of NBS and a trace of dibenzoyl peroxide. The mixture is heated to 80° C. and allowed to react for 6 hours. The yield of AMD--CH2Br is 70-80%. The brominated derivative is then reacted further with aminocaprioic acid to yield an AMD-aminocaproic acid complex (AMD--CH2NH (CH2)5COOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05155210 |
|---|
| Source dataset | uspto-grants-1992_10 |
|---|
| ORD ID | ord-df38a86a642f4dd8a884cf46d0df63d0 |
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| Source note | uspto-grants-1992_10 |
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