HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → Ciprofloxacin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ciprofloxacin | HCID 2764 | 93.4% |
Reaction Steps
26.7 parts by weight of piperazine and 26.5 parts by weight of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid in 200 parts by volume of water are heated to 120° C. in an autoclave for 60 minutes and the mixture is then worked up as in Example 1. 30.9 parts by weight (93.4% of theory) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1piperazinyl)-3quinolinecarboxylic acid are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05155223 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-fb0ded2a33284c26994d8bb31e2cfede |
| Source note | uspto-grants-1992_10 |