HCID 20077842, compound → HCID 20077844, compound

HRID 466259Notes

Reaction equation

HRID 466259 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:20]1([C:14]2([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 2

HCID 20077842HCID 20077842, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20077844HCID 20077844, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent2×

Procedure

1 benzyl 4 (1-phenylcyclohexyl)piperazine (0.47 q) was dissolved in 86 mL methanol and 14 mL 0.2 N HCI in methanol. The mixture was hydrogenated over palladium black (0.1175 g) and 3 atm. of hydrogen at room temperature for 1 hour. The reaction was filtered and the solvent was removed in vacuo. The residue was chromatographed on silica gel eluted with the appropriate mixture of methanol and chloroform to yield pure 1 (1-phenylcyclohexyl)piperazine.

Workup

  1. filtrationThe reaction was filtered
  2. customthe solvent was removed in vacuo
  3. customThe residue was chromatographed on silica gel
  4. washeluted with the appropriate mixture of methanol and chloroform

Sources & evidence

ORD record
ord-fada292287f74b86a73b257cfbd2fcf7
Source dataset
uspto-grants-1992_10
Patent number
US05155212

Reaction notes

Loading…