HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 466280Generated: October 29, 2026
1-Propene, 1,1-diethoxy- → Trans-2,2-diethoxy-3,6-dimethyl-4-acetylamino-5-(4'-chlorophenylcarbamoyl)-3,4-dihydro-2H-pyran
https://huagongshe.com/reaction/466280
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Propene, 1,1-diethoxy- | HCID 140841 | — |
| Reactant | HCID 178474785 | HCID 178474785 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Trans-2,2-diethoxy-3,6-dimethyl-4-acetylamino-5-(4'-chlorophenylcarbamoyl)-3,4-dihydro-2H-pyran | HCID 86746202 | — |
Reaction Steps
N-(4'-chlorophenyl)-2-(acetylaminomethylene)-3-oxobutanamide (83 g) in toluene (200 ml) was treated with 1,1-diethoxyprop-1-ene (60 ml) and heated at 100° C. for 6 hours. The mixture was evaporated and the residue was triturated with toluene to give trans-2,2-diethoxy-3,6-dimethyl-4-(acetylamino)-5-(4'-chlorophenylcarbamoyl)-3,4-dihydro-2H-pyran (80.5 g) m.p. 199°-201° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05155236 |
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| Source dataset | uspto-grants-1992_10 |
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| ORD ID | ord-4590463a90754ed795711203045b794f |
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| Source note | uspto-grants-1992_10 |
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