Acetamide → HCID 178500808, compound

HRID 466281Notes

Reaction equation

HRID 466281 reaction equation
[C:1]([NH2:4])(=[O:3])[CH3:2].CO[CH:7]=[C:8]([C:13](=[O:15])[CH3:14])[C:9]([O:11][CH3:12])=[O:10]>>[C:1]([NH:4][CH:7]=[C:8]([C:13](=[O:15])[CH3:14])[C:9]([O:11][CH3:12])=[O:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 178AcetamideHCID 54260517Methyl alpha-methoxymethyleneacetoacetate

Product 1

HCID 178500808HCID 178500808, compound

Conditions

Temperature
100 °C

Procedure

Acetamide (10.0 g) and methyl 2-methoxymethylene-3-oxobutanoate (30.0 ml) were heated with stirring at 100° C. for 4 hours. On cooling the product was flash chromatographed on Merck silica 9385 using a 50/50 mixture of ether/hexane to give the title compound (18.5 g) m.p. 60°-62° C. (hexane/ether).

Workup

  1. temperatureOn cooling the product
  2. customchromatographed on Merck silica 9385 using
  3. additiona 50/50 mixture of ether/hexane

Sources & evidence

ORD record
ord-57b1baffbd954deba8ebb09aed5b8ab2
Source dataset
uspto-grants-1992_10
Patent number
US05155236

Reaction notes

Loading…